0000950170-22-024611 | 10-Q | XBRL Viewer

Stock-Based Compensation - Summary of Share-based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended	9 Months Ended
Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total stock-based compensation expense	$ 1,783	$ 1,236	$ 5,096	$ 2,583
Research and Development Expense [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total stock-based compensation expense	657	297	1,872	626
General and Administrative Expense [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total stock-based compensation expense	$ 1,126	$ 939	$ 3,224	$ 1,957

Net Loss Per Share Attributable to Common Stockholders - Additional Information (Details)	9 Months Ended
Sep. 30, 2022
Earnings Per Share [Abstract]
Unit conversion ratio	1-for-1

Investments - Investments in a continual unrealized loss position (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Debt Securities, Available-for-Sale [Line Items]
Total available-for-sale securities	$ 41,933	$ 64,109
Continuous unrealized loss position, 12 months or longer	16,499	0
Corporate Bonds [Member]
Debt Securities, Available-for-Sale [Line Items]
Total available-for-sale securities	15,425	60,114
Continuous unrealized loss position, 12 months or longer	12,589	0
US Government Debt Securities [Member]
Debt Securities, Available-for-Sale [Line Items]
Total available-for-sale securities	26,508	0
Continuous unrealized loss position, 12 months or longer	3,910	0
Commercial Paper [Member]
Debt Securities, Available-for-Sale [Line Items]
Total available-for-sale securities	$ 0	$ 3,995

Stock-Based Compensation - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		9 Months Ended		12 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2018	Dec. 31, 2021
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Employees Including Executive Officers Earning Contribution			15.00%
Option Granted			1,673,932
Share-Based Payment Arrangement, Expense	$ 1,783	$ 1,236	$ 5,096	$ 2,583
Percentage of fair market value, common stock	85.00%		85.00%
Number of shares, Granted					21,750
Restricted Stock
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based payment award, award vesting rights, percentage			25.00%
Share-Based Payment Arrangement, Expense			$ 200
Common stock reserved for future issuance						21,750
Number of shares, Granted			0
Stock Options
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based payment award, award vesting rights, percentage			25.00%
Share-based payment award, option vesting period			4 years
Options grants in period, weighted average grant date fair value			$ 5.31
Unrecognized compensation cost	$ 16,100		$ 16,100
Unrecognized compensation, weighted average amortization period			2 years 8 months 26 days
Unvested Restricted Stock Awards [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Unrecognized compensation cost	$ 1,600		$ 1,600
Unrecognized compensation, weighted average amortization period			2 years 6 months 10 days
2019 Equity Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based payment award, description			Under the terms of the 2019 Plan, options are granted at an exercise price no less than fair value of the Company’s common stock on the grant date, except in certain cases related to employees outside of the U.S. However, for any employee who is a 10% or greater stockholder, options are granted at an exercise price no less than 110% of the fair value of the Company’s common stock on the grant date. Option awards granted typically have 10-year terms measured from the option grant date. However, if any employee is a 10% or greater stockholder, the awards have 5-year terms measured from the option grant date. While no shares are available for future issuance under the 2019 Plan, it continues to govern outstanding equity awards granted thereunder.
Share based payment award, purchase price of common stock, percent			110.00%
Share-based payment award, expiration period			10 years
2019 Equity Incentive Plan \| Employee is 10% or Greater Stockholder [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based payment award, expiration period			5 years
2021 Equity Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based payment award, expiration period			10 years
Share-based payment award, number of shares authorized	3,887,174		3,887,174
Number of Shares of Common Stock Outstanding Percentage			5.00%
ESPP
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based payment award, description			The ESPP allows employees, including executive officers, to contribute up to 15% of their earnings, subject to certain limitations, for the purchase of the Company's common stock at a price per share equal to the lower of (a) 85% of the fair market value of a share of common stock on the first day of the offering period, or (b) 85% of the fair market value of a share of common stock on the last day of the offering period. As of September 30, 2022, there were 521,555 shares of common stock reserved for future issuance under the ESPP. The number of shares of common stock reserved for issuance under the ESPP will automatically increase on January 1 of each calendar year, beginning on January 1, 2022 and continuing through and including January 1, 2031, by the lesser of (1) 1% of the total number of shares of the Company's common stock outstanding on December 31 of the preceding calendar year or (2) a number of shares determined by the Company's board of directors. Shares subject to purchase rights granted under the ESPP that terminate without having been exercised in full will not reduce the number of shares available for issuance under the ESPP.As of September 30, 2022, no shares have been granted or purchased under the ESPP.
Common stock reserved for future issuance	521,555		521,555
Number of Shares of Common Stock Outstanding Percentage			1.00%
Number of shares, Granted			0

Net Loss Per Share Attributable to Common Stockholders

9 Months Ended

Sep. 30, 2022

Earnings Per Share [Abstract]

Net Loss Per Share Attributable to Common Stockholders

8. Net Loss Per Share Attributable to Common Stockholders

The following table shows the computation of basic and diluted net loss per share (in thousands, except share and per share data):


	Three Months Ended September 30,						Nine Months Ended September 30,
	2022			2021			2022			2021
Net loss	$	(9,682	)	$	(9,615	)	$	(37,482	)	$	(36,935	)
Accretion of redeemable convertible preferred stock to redemption value and cumulative preferred stock dividends		—			(1,322	)		—			(4,548	)
Net loss attributable to common stockholders		(9,682	)		(10,937	)		(37,482	)		(41,483	)
Weighted-average common shares used to compute net loss per share attributable to common stockholders, basic and diluted		26,336,029			15,585,611			26,290,868			7,554,300
Net loss per share attributable to common stockholders, basic and diluted	$	(0.37	)	$	(0.70	)	$	(1.43	)	$	(5.49	)

All outstanding shares of redeemable convertible preferred stock were converted on a 1-for-1 basis to shares of common stock on August 12, 2021, the date of the Company's IPO (see Note 1). The cumulative preferred stock dividend was therefore eliminated upon conversion of the redeemable convertible preferred stock.

The following outstanding shares of potentially dilutive securities were excluded from the computation of the diluted net loss per share attributable to common stockholders for the periods presented because their effect would have been anti-dilutive:


	Three and Nine Months Ended September 30,
	2022		2021
Common stock options		4,533,421		2,737,315
Unvested restricted stock awards		219,310		348,639
Total potentially dilutive shares		4,752,731		3,085,954

Stock-Based Compensation

9 Months Ended

Sep. 30, 2022

Share-Based Payment Arrangement [Abstract]

Stock-Based Compensation

7. Stock-Based Compensation

2019 Plan

In 2019, the Company adopted the 2019 Equity Incentive Plan (the 2019 Plan). The 2019 Plan provides for the Company to grant qualified stock options, non-qualified stock options, and restricted stock awards to employees, non-employee directors and consultants of the Company under terms and provisions established by the Company's board of directors. Under the terms of the 2019 Plan, options are granted at an exercise price no less than fair value of the Company’s common stock on the grant date, except in certain cases related to employees outside of the U.S. However, for any employee who is a 10% or greater stockholder, options are granted at an exercise price no less than 110% of the fair value of the Company’s common stock on the grant date. Option awards granted typically have 10-year terms measured from the option grant date. However, if any employee is a 10% or greater stockholder, the awards have 5-year terms measured from the option grant date. While no shares are available for future issuance under the 2019 Plan, it continues to govern outstanding equity awards granted thereunder.

2021 Plan and ESPP

The compensation committee of the Company's board of directors adopted and the Company's stockholders approved the 2021 Equity Incentive Plan (2021 Plan) and the 2021 Employee Stock Purchase Plan (the ESPP), which became effective immediately prior to the effectiveness of the Company's IPO. The 2021 Plan provides for the grant of incentive stock options, non-statutory stock options, restricted stock awards, restricted stock units, stock appreciation rights and other stock-based awards. The Company's employees, officers, directors and consultants are eligible to receive awards under the 2021 Plan. Under the terms of the 2021 Plan, options are granted at an exercise price no less than fair value of the Company’s common stock on the grant date, except in certain cases related to significant corporate transactions. Option awards granted typically have 10-year terms measured from the option grant date. As of September 30, 2022, the total number of shares authorized for issuance under the 2021 Plan was 3,887,174. In addition, the number of shares of common stock reserved for issuance under the 2021 Plan will automatically increase on January 1 of each year, beginning on January 1, 2022, and continuing through and including January 1, 2031, by 5% of the total number of shares of common stock outstanding on December 31 of the immediately preceding calendar year, or a lesser number of shares determined by the Company's board of directors prior to the applicable January 1st.

The ESPP allows employees, including executive officers, to contribute up to 15% of their earnings, subject to certain limitations, for the purchase of the Company's common stock at a price per share equal to the lower of (a) 85% of the fair market value of a share of common stock on the first day of the offering period, or (b) 85% of the fair market value of a share of common stock on the last day of the offering period. As of September 30, 2022, there were 521,555 shares of common stock reserved for future issuance under the ESPP. The number of shares of common stock reserved for issuance under the ESPP will automatically increase on January 1 of each calendar year, beginning on January 1, 2022 and continuing through and including January 1, 2031, by the lesser of (1) 1% of the total number of shares of the Company's common stock outstanding on December 31 of the preceding calendar year or (2) a number of shares determined by the Company's board of directors. Shares subject to purchase rights granted under the ESPP that terminate without having been exercised in full will not reduce the number of shares available for issuance under the ESPP.

As of September 30, 2022, no shares have been granted or purchased under the ESPP.

Stock Options

Awards with vesting conditions under both plans typically include either (i) vesting 25% on the first anniversary of the grant date with the remainder vesting monthly over the following three years or (ii) monthly vesting over four years.

The activity for stock options is as follows:


	Options Outstanding			Weighted Average Exercise Price		Weighted Average Remaining Contract Terms (in years)		Aggregate Intrinsic Values (in thousands)
Balance as of December 31, 2021		2,922,135		$	3.62		9.14	$	21,144
Options granted		1,673,932			7.80
Options cancelled and forfeited		(62,646	)		4.18
Options exercised		—			—				—
Balance as of September 30, 2022		4,533,421		$	5.16		8.71	$	4,285
Vested and expected to vest, September 30, 2022(1)		4,488,421		$	5.13		8.71	$	4,285
Options exercisable as of September 30, 2022		1,499,959		$	3.25		8.27	$	2,338

(1) Excludes 45,000 stock options awards outstanding for the period ended September 30, 2022, subject to only performance conditions that have been assessed and deemed not probable.

The aggregate intrinsic value disclosed in the above table is based on the difference between the exercise price of stock options and the fair value of the Company’s common stock as of the respective period-end dates. The weighted-average grant date fair value of stock options granted during the nine months ended September 30, 2022, was $5.31 per share.

The Black-Scholes option pricing model for employee and nonemployee stock options incorporates the following assumptions:

•

Fair Value of Common Stock — Prior to the completion of the Company's IPO, the fair value of the Company's common stock was determined by using straight-line interpolation between the value of common stock derived from valuations performed by independent third party specialists, further described in Note 2 to the consolidated financial statements Summary of Significant Accounting Policies – Fair Value of Common Stock in the Company's Annual Report on Form 10-K filed with the SEC on March 7, 2022. After the completion of the Company's IPO, the fair value of each share of common stock is based on the closing price of the Company's common stock on the date of grant as reported on the Nasdaq Global Market.

•

Volatility — The expected stock price volatilities are estimated based on the historical and implied volatilities of comparable publicly traded companies as the Company does not have sufficient history of trading its common stock.

•

Risk-free Interest Rate — The risk-free interest rates are based on US Treasury yields in effect at the grant date for notes with comparable terms as the awards.

•

Expected Term — The expected term represents the period that the Company’s stock options are expected to be outstanding and is determined using the simplified method (based on the mid-point between the vesting date and the end of the contractual term).

•

Dividend Yield — The expected dividend yield assumption is based on the Company’s current expectations about its anticipated dividend policy.

The fair value of the Company’s stock option awards was estimated at the date of grant using a Black-Scholes option pricing model with the following assumptions for the nine months ended September 30, 2022:


Expected term (in years)		5.50 - 6.50
Expected volatility		77.33% - 80.54%
Risk-free interest rate		1.69% - 3.03%
Expected dividend yield		0.00%

Restricted Stock

The Company has restricted stock awards with service conditions that vest 25% on the first anniversary of the grant date and monthly thereafter. The restricted stock awards are subject to repurchase by the Company at the original purchase price in the event that the award recipient’s employment or relationship is terminated prior to the shares vesting.

In 2018, the Company granted restricted stock awards with performance conditions that vested upon the Company’s initiation of a registrational clinical trial to study the efficacy of ETX-810. The probability of achieving performance conditions is assessed each reporting period. As of December 31, 2021, 21,750 of these awards were still outstanding, and the Company recognized no stock-based compensation expense relating to these awards, as the performance condition was assessed and deemed not probable. In January 2022, the Company’s board of directors approved a modification to the vesting terms of these awards, such that the awards will vest in full on October 24, 2022. The incremental stock-based compensation expense related to the modification of these awards is $0.2 million, which is being recognized prospectively from the modification date through the vesting date.

The activity for restricted stock awards is as follows:


	Number of Shares			Weighted-Average Grant Date Fair Value
Unvested at December 31, 2021(1)		332,364		$	7.30
Granted		—			—
Vested		(113,054	)		7.95
Forfeited		—			—
Unvested at September 30, 2022		219,310		$	7.46

(1) Includes 21,750 restricted stock awards granted in 2018 and still outstanding at December 31, 2021, subject to only performance conditions.

Stock-Based Compensation

The following table sets forth stock-based compensation for stock options, restricted stock awards, and performance awards included in the Company’s condensed consolidated statements of operations and comprehensive loss (in thousands):


	Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021
Research and development expense	$	657	$	297	$	1,872	$	626
General and administrative expense		1,126		939		3,224		1,957
Total stock-based compensation expense	$	1,783	$	1,236	$	5,096	$	2,583

As of September 30, 2022, there was $16.1 million of total unrecognized compensation cost related to unvested stock options and unvested restricted stock awards granted and $1.6 million of unrecognized compensation cost related to unvested restricted stock awards granted, which is expected to be recognized over a weighted average period of 2.74 years and 2.53 years, respectively.

Net Loss Per Share Attributable to Common Stockholders - Schedule of Basic and Diluted Net Loss Per Share (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Earnings Per Share [Abstract]
Net loss	$ (9,682)	$ (9,615)	$ (37,482)	$ (36,935)
Accretion of redeemable convertible preferred stock to redemption value and cumulative preferred stock dividends	0	(1,322)	0	(4,548)
Net loss attributable to common stockholders	$ (9,682)	$ (10,937)	$ (37,482)	$ (41,483)
Weighted-average number of shares outstanding used to compute net loss per share attributable to common stockholders, basic	26,336,029	15,585,611	26,290,868	7,554,300
Weighted-average number of shares outstanding used to compute net loss per share attributable to common stockholders, diluted	26,336,029	15,585,611	26,290,868	7,554,300
Net loss per share attributable to common stockholders, Basic	$ (0.37)	$ (0.70)	$ (1.43)	$ (5.49)
Net loss per share attributable to common stockholders, Diluted	$ (0.37)	$ (0.70)	$ (1.43)	$ (5.49)

- Definition

The amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 815
-SubTopic 40
-Section 65
-Paragraph 1
-Subparagraph (e)(4)
-URI https://asc.fasb.org/extlink&oid=126732423&loc=SL123482106-238011

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 3
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22583-107794

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 11
-Subparagraph (b)
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22694-107794

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 45
-Paragraph 10
-URI https://asc.fasb.org/extlink&oid=126958026&loc=d3e1448-109256

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 4
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22595-107794

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 11
-Subparagraph (a)
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22694-107794

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 45
-Paragraph 7
-URI https://asc.fasb.org/extlink&oid=126958026&loc=d3e1337-109256

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 815
-SubTopic 40
-Section 65
-Paragraph 1
-Subparagraph (f)
-URI https://asc.fasb.org/extlink&oid=126732423&loc=SL123482106-238011

Reference 9: http://www.xbrl.org/2003/role/exampleRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 55
-Paragraph 52
-URI https://asc.fasb.org/extlink&oid=128363288&loc=d3e4984-109258

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 944
-SubTopic 220
-Section S99
-Paragraph 1
-Subparagraph (SX 210.7-04(23))
-URI https://asc.fasb.org/extlink&oid=120400993&loc=SL114874131-224263

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 55
-Paragraph 15
-URI https://asc.fasb.org/extlink&oid=128363288&loc=d3e3842-109258

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 7
-Subparagraph (a)
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22644-107794

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (a)
-URI https://asc.fasb.org/extlink&oid=124432515&loc=d3e3550-109257

Reference 14: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03(25))
-URI https://asc.fasb.org/extlink&oid=126953954&loc=SL114868664-224227

Reference 15: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 45
-Paragraph 2
-URI https://asc.fasb.org/extlink&oid=126958026&loc=d3e1252-109256

Reference 16: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 45
-Paragraph 60B
-Subparagraph (d)
-URI https://asc.fasb.org/extlink&oid=126958026&loc=SL5780133-109256

Reference 17: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 942
-SubTopic 220
-Section S99
-Paragraph 1
-Subparagraph (SX 210.9-04(27))
-URI https://asc.fasb.org/extlink&oid=120399700&loc=SL114874048-224260

+ Details

- Definition

The amount of net income (loss) for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.

+ References

Reference 1: http://www.xbrl.org/2003/role/exampleRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 55
-Paragraph 52
-URI https://asc.fasb.org/extlink&oid=128363288&loc=d3e4984-109258

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 7
-Subparagraph (a)
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22644-107794

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 55
-Paragraph 15
-URI https://asc.fasb.org/extlink&oid=128363288&loc=d3e3842-109258

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 45
-Paragraph 2
-URI https://asc.fasb.org/extlink&oid=126958026&loc=d3e1252-109256

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 11
-Subparagraph (b)
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22694-107794

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 4
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22595-107794

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 3
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22583-107794

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 45
-Paragraph 60B
-Subparagraph (d)
-URI https://asc.fasb.org/extlink&oid=126958026&loc=SL5780133-109256

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 815
-SubTopic 40
-Section 65
-Paragraph 1
-Subparagraph (f)
-URI https://asc.fasb.org/extlink&oid=126732423&loc=SL123482106-238011

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 942
-SubTopic 220
-Section S99
-Paragraph 1
-Subparagraph (SX 210.9-04(27))
-URI https://asc.fasb.org/extlink&oid=120399700&loc=SL114874048-224260

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (a)
-URI https://asc.fasb.org/extlink&oid=124432515&loc=d3e3550-109257

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 944
-SubTopic 220
-Section S99
-Paragraph 1
-Subparagraph (SX 210.7-04(23))
-URI https://asc.fasb.org/extlink&oid=120400993&loc=SL114874131-224263

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 11
-Subparagraph (a)
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22694-107794

Reference 14: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 45
-Paragraph 7
-URI https://asc.fasb.org/extlink&oid=126958026&loc=d3e1337-109256

Reference 15: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 815
-SubTopic 40
-Section 65
-Paragraph 1
-Subparagraph (e)(4)
-URI https://asc.fasb.org/extlink&oid=126732423&loc=SL123482106-238011

Reference 16: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03(25))
-URI https://asc.fasb.org/extlink&oid=126953954&loc=SL114868664-224227

+ Details

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 942
-SubTopic 220
-Section S99
-Paragraph 1
-Subparagraph (SX 210.9-04(22))
-URI https://asc.fasb.org/extlink&oid=120399700&loc=SL114874048-224260

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 32
-Subparagraph (f)
-URI https://asc.fasb.org/extlink&oid=126901519&loc=d3e8933-108599

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 4
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22595-107794

Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 944
-SubTopic 220
-Section S99
-Paragraph 1
-Subparagraph (SX 210.7-04(18))
-URI https://asc.fasb.org/extlink&oid=120400993&loc=SL114874131-224263

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 815
-SubTopic 40
-Section 65
-Paragraph 1
-Subparagraph (f)
-URI https://asc.fasb.org/extlink&oid=126732423&loc=SL123482106-238011

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section 50
-Paragraph 6
-URI https://asc.fasb.org/extlink&oid=124431353&loc=SL124452729-227067

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-SubTopic 10
-Section S99
-Paragraph 1B
-Subparagraph (SX 210.13-02(a)(5))
-URI https://asc.fasb.org/extlink&oid=126975872&loc=SL124442552-122756

Reference 8: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03(20))
-URI https://asc.fasb.org/extlink&oid=126953954&loc=SL114868664-224227

Reference 9: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 28
-URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3602-108585

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (b)(2)
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22499-107794

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-SubTopic 10
-Section S99
-Paragraph 1A
-Subparagraph (SX 210.13-01(a)(4)(iv))
-URI https://asc.fasb.org/extlink&oid=126975872&loc=SL124442526-122756

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-SubTopic 10
-Section S99
-Paragraph 1A
-Subparagraph (SX 210.13-01(a)(4)(iii)(A))
-URI https://asc.fasb.org/extlink&oid=126975872&loc=SL124442526-122756

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-SubTopic 10
-Section S99
-Paragraph 1B
-Subparagraph (SX 210.13-02(a)(4)(i))
-URI https://asc.fasb.org/extlink&oid=126975872&loc=SL124442552-122756

Reference 14: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-SubTopic 10
-Section S99
-Paragraph 1A
-Subparagraph (SX 210.13-01(a)(4)(i))
-URI https://asc.fasb.org/extlink&oid=126975872&loc=SL124442526-122756

Reference 15: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 9
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22663-107794

Reference 16: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-SubTopic 10
-Section S99
-Paragraph 1B
-Subparagraph (SX 210.13-02(a)(4)(iv))
-URI https://asc.fasb.org/extlink&oid=126975872&loc=SL124442552-122756

Reference 17: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-SubTopic 10
-Section S99
-Paragraph 1A
-Subparagraph (SX 210.13-01(a)(4)(ii))
-URI https://asc.fasb.org/extlink&oid=126975872&loc=SL124442526-122756

Reference 18: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
-SubTopic 10
-Section 50
-Paragraph 28
-Subparagraph (f)
-URI https://asc.fasb.org/extlink&oid=123596393&loc=d3e14064-108612

Reference 19: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 3
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22583-107794

Reference 20: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(g)(1)(ii))
-URI https://asc.fasb.org/extlink&oid=120395691&loc=d3e23780-122690

Reference 21: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 45
-Paragraph 60B
-Subparagraph (a)
-URI https://asc.fasb.org/extlink&oid=126958026&loc=SL5780133-109256

Reference 22: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 323
-SubTopic 10
-Section 50
-Paragraph 3
-Subparagraph (c)
-URI https://asc.fasb.org/extlink&oid=114001798&loc=d3e33918-111571

Reference 23: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 8
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22658-107794

Reference 24: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section 45
-Paragraph 1A
-Subparagraph (a)
-URI https://asc.fasb.org/extlink&oid=126968391&loc=SL7669619-108580

Reference 25: http://www.xbrl.org/2003/role/exampleRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 31
-URI https://asc.fasb.org/extlink&oid=126901519&loc=d3e8924-108599

Reference 26: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 11
-Subparagraph (b)
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22694-107794

Reference 27: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 11
-Subparagraph (a)
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22694-107794

Reference 28: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 205
-SubTopic 20
-Section 50
-Paragraph 7
-URI https://asc.fasb.org/extlink&oid=109222650&loc=SL51721683-107760

Reference 29: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section 45
-Paragraph 1B
-Subparagraph (a)
-URI https://asc.fasb.org/extlink&oid=126968391&loc=SL7669625-108580

Reference 30: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 22
-URI https://asc.fasb.org/extlink&oid=126901519&loc=d3e8736-108599

Reference 31: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-SubTopic 10
-Section S99
-Paragraph 1A
-Subparagraph (SX 210.13-01(a)(5))
-URI https://asc.fasb.org/extlink&oid=126975872&loc=SL124442526-122756

Reference 32: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-SubTopic 10
-Section S99
-Paragraph 1B
-Subparagraph (SX 210.13-02(a)(4)(iii)(B))
-URI https://asc.fasb.org/extlink&oid=126975872&loc=SL124442552-122756

Reference 33: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-SubTopic 10
-Section S99
-Paragraph 1B
-Subparagraph (SX 210.13-02(a)(4)(iii)(A))
-URI https://asc.fasb.org/extlink&oid=126975872&loc=SL124442552-122756

Reference 34: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 30
-Subparagraph (b)
-URI https://asc.fasb.org/extlink&oid=126901519&loc=d3e8906-108599

Reference 35: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 32
-Subparagraph (c)
-URI https://asc.fasb.org/extlink&oid=126901519&loc=d3e8933-108599

+ Details

- Definition

Amount, after deduction of tax, noncontrolling interests, dividends on preferred stock and participating securities; of income (loss) available to common shareholders.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 4
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22595-107794

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 45
-Paragraph 10
-URI https://asc.fasb.org/extlink&oid=126958026&loc=d3e1448-109256

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 11
-Subparagraph (a)
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22694-107794

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 45
-Paragraph 11
-URI https://asc.fasb.org/extlink&oid=126958026&loc=d3e1377-109256

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (a)
-URI https://asc.fasb.org/extlink&oid=124432515&loc=d3e3550-109257

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 22
-URI https://asc.fasb.org/extlink&oid=126901519&loc=d3e8736-108599

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 11
-Subparagraph (b)
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22694-107794

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 45
-Paragraph 60B
-Subparagraph (c)
-URI https://asc.fasb.org/extlink&oid=126958026&loc=SL5780133-109256

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 32
-Subparagraph (f)
-URI https://asc.fasb.org/extlink&oid=126901519&loc=d3e8933-108599

Reference 10: http://www.xbrl.org/2003/role/exampleRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 31
-URI https://asc.fasb.org/extlink&oid=126901519&loc=d3e8924-108599

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 30
-Subparagraph (b)
-URI https://asc.fasb.org/extlink&oid=126901519&loc=d3e8906-108599

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 3
-URI https://asc.fasb.org/extlink&oid=124431687&loc=d3e22583-107794

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 32
-Subparagraph (c)
-URI https://asc.fasb.org/extlink&oid=126901519&loc=d3e8933-108599

+ Details

Description of Organization and Summary of Significant Accounting Policies - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands			3 Months Ended	9 Months Ended
	Jan. 01, 2022	Aug. 12, 2021	Sep. 30, 2022	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2021
Subsidiary Sale Of Stock [Line Items]
Proceeds from issuance initial public offering					$ 83,144
Convertible preferred stock, shares issued upon conversion			152,800,000	152,800,000
Accumulated deficit			$ (113,098)	$ (113,098)		$ (75,616)
Right-of-use assets obtained in exchange for lease liabilities	$ 900			915	$ 0
Total operating lease liabilities	900		571	$ 571
Derecognized deferred rent and other lease liabilities	$ 12,000
Entity incorporation date				Oct. 18, 2018
Cash, cash equivalents and marketable securities			129,600	$ 129,600
Change in estimate			1,500
Fair Value Inputs Level 1, 2 and 3 [Member]
Subsidiary Sale Of Stock [Line Items]
Fair value transfer amount			$ 0	$ 0
IPO [Member]
Subsidiary Sale Of Stock [Line Items]
Proceeds from issuance of common stock in initial public offering, Shares		7,360,000
Shares issued price per share		$ 12.50
Proceeds from issuance initial public offering		$ 92,000
Proceeds from issuance initial public offering net		$ 83,100
Convertible preferred stock, shares issued upon conversion		15,345,279
Deferred offering costs		$ 2,500
Underwriting Discount		$ 6,400

Net Loss Per Share Attributable to Common Stockholders (Tables)

9 Months Ended

Sep. 30, 2022

Earnings Per Share [Abstract]

Schedule of Basic and Diluted Net Loss Per Share

The following table shows the computation of basic and diluted net loss per share (in thousands, except share and per share data):


	Three Months Ended September 30,						Nine Months Ended September 30,
	2022			2021			2022			2021
Net loss	$	(9,682	)	$	(9,615	)	$	(37,482	)	$	(36,935	)
Accretion of redeemable convertible preferred stock to redemption value and cumulative preferred stock dividends		—			(1,322	)		—			(4,548	)
Net loss attributable to common stockholders		(9,682	)		(10,937	)		(37,482	)		(41,483	)
Weighted-average common shares used to compute net loss per share attributable to common stockholders, basic and diluted		26,336,029			15,585,611			26,290,868			7,554,300
Net loss per share attributable to common stockholders, basic and diluted	$	(0.37	)	$	(0.70	)	$	(1.43	)	$	(5.49	)

Schedule of Antidilutive Securities Excluded from Computation of Net Loss Per Share Attributable to Common Stockholders


	Three and Nine Months Ended September 30,
	2022		2021
Common stock options		4,533,421		2,737,315
Unvested restricted stock awards		219,310		348,639
Total potentially dilutive shares		4,752,731		3,085,954

Stock-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2022

Share-Based Payment Arrangement [Abstract]

Summary of Stock Option Activities

The activity for stock options is as follows:


	Options Outstanding			Weighted Average Exercise Price		Weighted Average Remaining Contract Terms (in years)		Aggregate Intrinsic Values (in thousands)
Balance as of December 31, 2021		2,922,135		$	3.62		9.14	$	21,144
Options granted		1,673,932			7.80
Options cancelled and forfeited		(62,646	)		4.18
Options exercised		—			—				—
Balance as of September 30, 2022		4,533,421		$	5.16		8.71	$	4,285
Vested and expected to vest, September 30, 2022(1)		4,488,421		$	5.13		8.71	$	4,285
Options exercisable as of September 30, 2022		1,499,959		$	3.25		8.27	$	2,338

Summary of Assumptions Used in Black-Scholes Model


Expected term (in years)		5.50 - 6.50
Expected volatility		77.33% - 80.54%
Risk-free interest rate		1.69% - 3.03%
Expected dividend yield		0.00%

Summary of Restricted Stock Awards

The activity for restricted stock awards is as follows:


	Number of Shares			Weighted-Average Grant Date Fair Value
Unvested at December 31, 2021(1)		332,364		$	7.30
Granted		—			—
Vested		(113,054	)		7.95
Forfeited		—			—
Unvested at September 30, 2022		219,310		$	7.46

Summary of Share-based Compensation Expense


	Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021
Research and development expense	$	657	$	297	$	1,872	$	626
General and administrative expense		1,126		939		3,224		1,957
Total stock-based compensation expense	$	1,783	$	1,236	$	5,096	$	2,583

Investments (Tables)

9 Months Ended

Sep. 30, 2022

Investments [Abstract]

Investments consists of available-for-sale securities

Investments consists of available-for-sale securities as follows (in thousands):


	September 30, 2022
	Amortized Cost		Unrealized Gain		Unrealized Loss			Estimated Fair Value
Short-term marketable securities:
Commercial paper	$	30,318	$	—	$	—		$	30,318
U.S. government debt securities		35,531		—		(227	)		35,304
Corporate bonds		21,367		—		(314	)		21,053
Total short-term marketable securities	$	87,216	$	—	$	(541	)	$	86,675
Long-term marketable securities:
U.S. government debt securities	$	—	$	—	$	—		$	—
Corporate bonds		7,001		—		(40	)		6,961
Total long-term marketable securities	$	7,001	$	—	$	(40	)	$	6,961


	December 31, 2021
	Amortized Cost		Unrealized Gain		Unrealized Loss			Estimated Fair Value
Short-term marketable securities:
Commercial paper	$	54,363	$	—	$	(1	)	$	54,362
Corporate bonds		35,231		—		(35	)		35,196
Total short-term marketable securities	$	89,594	$	—	$	(36	)	$	89,558
Long-term marketable securities:
U.S. government debt securities	$	3,996	$	—	$	(17	)	$	3,979
Corporate bonds		21,010		—		(70	)		20,940
Total long-term marketable securities	$	25,006	$	—	$	(87	)	$	24,919

Investments in a continual unrealized loss position

Investments in a continual unrealized loss position for less than 12 months consist of the following (in thousands):


	September 30, 2022		December 31, 2021
	Fair Value		Fair Value
Corporate bonds	$	15,425	$	60,114
U.S. government debt securities		26,508		—
Commercial paper		—		3,995
Total available-for-sale securities	$	41,933	$	64,109

Investments in a continual unrealized loss position for greater than 12 months consist of the following (in thousands):


	September 30, 2022		December 31, 2021
	Fair Value		Fair Value
Corporate bonds	$	12,589	$	—
U.S. government debt securities		3,910		—
Total available-for-sale securities	$	16,499	$	—

Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 35,944	$ 46,922
Short-term marketable securities	86,675	89,558
Prepaid expenses and other current assets	10,552	11,772
Total current assets	133,171	148,252
Operating Lease, Right-of-Use Asset	585	0
Long-term marketable securities	6,961	24,919
Other long term assets	141	70
Total assets	140,858	173,241
Current liabilities:
Accounts payable	1,494	1,404
Accrued expenses	4,434	4,627
Operating lease liabilities	352	0
Total current liabilities	6,280	6,031
Other long-term liabilities	0	7
Operating lease liabilities, net of current portion	219	0
Total liabilities	6,499	6,038
Commitments and contingencies (Note 6)
Stockholders' equity
Common stock, $0.0001 par value per share, 250,000,000 shares authorized; 26,567,681 shares issued and outstanding at September 30, 2022 and December 31, 2021, respectively	3	3
Additional paid-in capital	248,035	242,939
Accumulated other comprehensive loss	(581)	(123)
Accumulated deficit	(113,098)	(75,616)
Total stockholders' equity	134,359	167,203
Total liabilities and stockholders' equity	$ 140,858	$ 173,241

Document and Entity Information - shares	9 Months Ended
Document and Entity Information - shares	Sep. 30, 2022	Nov. 10, 2022
Cover [Abstract]
Document Type	10-Q
Amendment Flag	false
Document Period End Date	Sep. 30, 2022
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	Q3
Entity Registrant Name	ELIEM THERAPEUTICS, INC.
Entity Central Index Key	0001768446
Current Fiscal Year End Date	--12-31
Entity Filer Category	Non-accelerated Filer
Entity Shell Company	false
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Small Business	true
Entity Emerging Growth Company	true
Entity Ex Transition Period	false
Entity File Number	001-40708
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	82-2273741
Entity Address, Address Line One	23515 NE Novelty Hill Road
Entity Address, Address Line Two	Suite B221 #125
Entity Address, City or Town	Redmond
Entity Address, State or Province	WA
Entity Address, Postal Zip Code	98053
City Area Code	425
Local Phone Number	276-2300
Document Transition Report	false
Title of 12(b) Security	Common Stock, par value $0.0001 per share
Trading Symbol	ELYM
Security Exchange Name	NASDAQ
Document Quarterly Report	true
Entity Common Stock, Shares Outstanding		26,567,681

Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Operating expenses:
Research and development	$ 4,258	$ 5,989	$ 21,287	$ 16,443
General and administrative	4,490	3,394	14,294	8,526
Total operating expenses	8,748	9,383	35,581	24,969
Loss from operations	(8,748)	(9,383)	(35,581)	(24,969)
Other income (expense):
Change in fair value of redeemable convertible preferred stock tranche liability	0	0	0	(11,718)
Foreign currency loss	(1,317)	(252)	(2,516)	(268)
Other income, net	383	20	615	20
Total other income (expense)	(934)	(232)	(1,901)	(11,966)
Net loss	(9,682)	(9,615)	(37,482)	(36,935)
Accretion of redeemable convertible preferred stock to redemption value and cumulative preferred stock dividends	0	(1,322)	0	(4,548)
Net loss attributable to common stockholders	$ (9,682)	$ (10,937)	$ (37,482)	$ (41,483)
Net loss per share attributable to common stockholders, Basic	$ (0.37)	$ (0.70)	$ (1.43)	$ (5.49)
Net loss per share attributable to common stockholders, Diluted	$ (0.37)	$ (0.70)	$ (1.43)	$ (5.49)
Weighted-average number of shares outstanding used to compute net loss per share attributable to common stockholders, basic	26,336,029	15,585,611	26,290,868	7,554,300
Weighted-average number of shares outstanding used to compute net loss per share attributable to common stockholders, diluted	26,336,029	15,585,611	26,290,868	7,554,300
Comprehensive loss:
Net loss	$ (9,682)	$ (9,615)	$ (37,482)	$ (36,935)
Other comprehensive loss
Unrealized gain (loss) on investments	23	18	(458)	(18)
Comprehensive loss	$ (9,659)	$ (9,633)	$ (37,940)	$ (36,953)

Investments

9 Months Ended

Sep. 30, 2022

Investments [Abstract]

Investments

2. Investments

Investments consists of available-for-sale securities as follows (in thousands):


	September 30, 2022
	Amortized Cost		Unrealized Gain		Unrealized Loss			Estimated Fair Value
Short-term marketable securities:
Commercial paper	$	30,318	$	—	$	—		$	30,318
U.S. government debt securities		35,531		—		(227	)		35,304
Corporate bonds		21,367		—		(314	)		21,053
Total short-term marketable securities	$	87,216	$	—	$	(541	)	$	86,675
Long-term marketable securities:
U.S. government debt securities	$	—	$	—	$	—		$	—
Corporate bonds		7,001		—		(40	)		6,961
Total long-term marketable securities	$	7,001	$	—	$	(40	)	$	6,961


	December 31, 2021
	Amortized Cost		Unrealized Gain		Unrealized Loss			Estimated Fair Value
Short-term marketable securities:
Commercial paper	$	54,363	$	—	$	(1	)	$	54,362
Corporate bonds		35,231		—		(35	)		35,196
Total short-term marketable securities	$	89,594	$	—	$	(36	)	$	89,558
Long-term marketable securities:
U.S. government debt securities	$	3,996	$	—	$	(17	)	$	3,979
Corporate bonds		21,010		—		(70	)		20,940
Total long-term marketable securities	$	25,006	$	—	$	(87	)	$	24,919

All the commercial paper, U.S. government debt securities, and corporate bonds designated as short-term marketable securities have a contractual maturity date that is equal to or less than one year from the respective balance sheet date. Those that are designated as long-term marketable securities have a contractual maturity date that is more than one year from the respective balance sheet date.

Accrued interest receivable is excluded from the amortized cost and estimated fair value of the Company's marketable securities. Accrued interest receivable of $0.2 million and $0.5 million is presented separately within the prepaid expenses and other current assets line items in the Company's unaudited condensed consolidated balance sheet as of September 30, 2022 and December 31, 2021, respectively.

Investments in a continual unrealized loss position for less than 12 months consist of the following (in thousands):


	September 30, 2022		December 31, 2021
	Fair Value		Fair Value
Corporate bonds	$	15,425	$	60,114
U.S. government debt securities		26,508		—
Commercial paper		—		3,995
Total available-for-sale securities	$	41,933	$	64,109

Investments in a continual unrealized loss position for greater than 12 months consist of the following (in thousands):


	September 30, 2022		December 31, 2021
	Fair Value		Fair Value
Corporate bonds	$	12,589	$	—
U.S. government debt securities		3,910		—
Total available-for-sale securities	$	16,499	$	—

As of September 30, 2022, the Company did not intend, nor was the Company more likely than not to be required, to sell its available-for-sale investments before the recovery of the amortized cost basis, which may be maturity. Therefore, the Company believes it is more likely than not that its marketable securities in an unrealized loss position will be held until maturity or the recovery of the cost basis of the investment. Based on the Company's assessment, it concluded that none of the available-for-sale investments held as of September 30, 2022 were considered to be impaired, as such, no impairment loss related to other-than-temporary declines in market value was recorded for the three and nine months ended September 30, 2022. There was no realized gain or loss on available-for-sale securities in the periods presented.

Description of Organization and Summary of Significant Accounting Policies

9 Months Ended

Sep. 30, 2022

Accounting Policies [Abstract]

Description of Organization and Summary of Significant Accounting Policies

1. Description of Organization and Summary of Significant Accounting Policies

Organization

Eliem Therapeutics, Inc. (the Company) is a clinical-stage biotechnology company focused on developing novel therapies for neuronal excitability disorders to address unmet needs in neuropsychiatry, epilepsy, chronic pain, and other disorders of the peripheral and central nervous systems. Headquartered in Redmond, Washington, the Company was incorporated on October 18, 2018 as a Delaware corporation.

Basis of Presentation and Principles of Consolidation

The accompanying interim condensed consolidated financial statements of the Company and its wholly owned subsidiary have been prepared in conformity with accounting principles generally accepted in the United States (U.S. GAAP). All intercompany transactions and balances have been eliminated in consolidation.

The accompanying condensed consolidated balance sheet as of September 30, 2022, and condensed consolidated statements of operations and comprehensive loss, condensed consolidated statements of cash flows, and condensed consolidated statements of redeemable convertible preferred stock and stockholders’ equity (deficit) for the three and nine months ended September 30, 2022 and 2021, are unaudited. The consolidated balance sheet as of December 31, 2021 was derived from the audited financial statements as of and for the year ended December 31, 2021, but does not include all disclosures required by U.S. GAAP. The unaudited interim condensed financial statements have been prepared on a basis consistent with the audited annual financial statements as of and for the year ended December 31, 2021, and, in the opinion of management, reflect all adjustments, consisting solely of normal recurring adjustments, necessary for the fair statement of the Company’s financial position as of September 30, 2022, the condensed results of its operations as of the three and nine months ended September 30, 2022 and 2021, and its cash flows for the nine months ended September 30, 2022 and 2021. The financial data and other information disclosed in these notes related to the three and nine months ended September 30, 2022 and 2021 are also unaudited. The condensed results of operations for the three and nine months ended September 30, 2022 are not necessarily indicative of the results to be expected for the full year ending December 31, 2022 or any other period. These interim condensed consolidated financial statements should be read in conjunction with the Company’s audited financial statements included in the Company's Annual Report on Form 10-K filed with the Securities and Exchange Commission, or SEC, on March 7, 2022.

Initial Public Offering

On August 12, 2021, the Company completed its initial public offering (IPO) of 7,360,000 shares of common stock, including the underwriters' full exercise of their over-allotment option at the IPO price of $12.50 per share. Gross proceeds from the IPO were $92.0 million, and the net proceeds were $83.1 million, after deducting underwriting discounts of $6.4 million and $2.5 million of offering costs payable by the Company. At the closing of the IPO, all of the Company's then outstanding redeemable convertible preferred stock was automatically converted into an aggregate of 15,345,279 shares of common stock. The related carrying value of the redeemable convertible preferred stock of $152.8 million was reclassified to common stock and additional paid-in capital.

Liquidity

Since inception, the Company has experienced recurring losses from operations and generated negative cash flows from operations. The Company has an accumulated deficit of $113.1 million as of September 30, 2022 and expects to incur additional losses from operations in the future. The Company estimates the available cash, cash equivalents, and short- and long-term marketable securities of $129.6 million as of September 30, 2022 will be sufficient to meet its projected operating requirements for at least the next twelve months from the filing date of these unaudited condensed consolidated financial statements.

The Company will need to obtain substantial additional funding to develop and commercialize the Company's clinical programs as currently contemplated. The Company expects to finance future cash needs through equity offerings, debt financings, collaborations, strategic alliances, licensing arrangements and other marketing and distribution arrangements. In addition, the Company expects to continue to rely on capital markets, and to a lesser extent, United Kingdom (U.K.) research and development tax credits and incentives for funding. There are no assurances that the Company will be able to raise sufficient amounts of funding in the future on acceptable terms, or at all.

Use of Estimates

The preparation of the interim condensed consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect reported amounts and disclosures. Accordingly, actual results could differ from those estimates. Key management estimates include those related to the accrual of research and development expenses, the valuation of stock-based awards, the valuation of common stock and redeemable convertible preferred stock, and the valuation of redeemable convertible preferred stock tranche liabilities. The Company evaluates its estimates and assumptions on an ongoing basis using historical experience and other factors and adjusts those estimates and assumptions when facts and circumstances dictate. Actual results could differ from those estimates.

The three months ended as of September 30, 2022 included a reversal of $1.5 million of clinical expenses due to actual results differing from prior quarter estimates.

Concentration of Credit Risk

Financial instruments that potentially subject the Company to concentrations of credit risk consist primarily of cash, cash equivalents, and short- and long-term marketable securities. The Company’s cash is held by two financial institutions in the United States (U.S.) and two financial institutions in the U.K. The Company does not believe that it is subject to unusual credit risk beyond the normal credit risk associated with commercial banking relationships. The Company’s deposits held in the U.S. and U.K. may exceed the Federal Depository Insurance Corporation and Financial Services Compensation Scheme, respectively, insured limits. The Company has investments in money market funds, U.S. government debt securities, commercial paper, and corporate bonds with high-quality accredited financial institutions.

Risks and Uncertainties

The Company is subject to risks and uncertainties common to early-stage companies in the biotechnology industry, including, but not limited to, development by competitors of new technological innovations, protection of proprietary technology, dependence on key personnel, reliance on single-source vendors and collaborators, availability of raw materials, patentability of the Company’s products and processes and clinical efficacy and safety of the Company’s products under development, compliance with government regulations and the need to obtain additional financing to fund operations. Product candidates currently under development will require significant additional research and development efforts, including extensive preclinical studies, clinical trials, and regulatory approval, prior to commercialization. These efforts will require significant amounts of additional capital, adequate personnel infrastructure and extensive compliance and reporting.

There can be no assurance that the Company’s research and development will be successfully completed, that adequate protection for the Company’s intellectual property will be obtained or maintained, that any products developed will obtain necessary government regulatory approval or that any approved products will be commercially viable. Even if the Company’s product development efforts are successful, it is uncertain when, if ever, the Company will generate revenue from product sales. The Company operates in an environment of rapid technological change and substantial competition from other pharmaceutical and biotechnology companies. In addition, the Company is dependent upon the services of its employees, consultants and other third parties.

Moreover, the ongoing COVID-19 pandemic, which is impacting worldwide economic activity, poses risk that the Company or its employees, contractors, suppliers, and other partners may be prevented from conducting business activities for an indefinite period of time which may increase costs and could delay the start-up and conduct of the Company’s clinical trials, and negatively impact manufacturing and testing activities performed by third parties. Any significant delays may impact the use and sufficiency of the Company’s existing cash reserves, and the Company may be required to raise additional capital earlier than it had previously planned. The Company may be unable to raise additional capital if and when needed, which may result in delays or suspension of its development plans. The extent to which the pandemic will impact the Company’s business will depend on future developments that are highly uncertain and cannot be predicted at this time.

Segments

Operating segments are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision-maker (the CODM). The Company’s CODM is its chief executive officer who reviews financial information together with certain operating metrics principally to make decisions about how to allocate resources and to measure the Company’s performance. Management has determined that the Company operates as a single operating and reportable segment. The Company’s CODM evaluates financial information on a consolidated basis. As the Company operates as one operating segment, all required segment financial information is found in the interim condensed consolidated financial statements.

Fair Value Measurement

Assets and liabilities recorded at fair value on a recurring basis in the balance sheet are categorized based upon the level of judgment associated with the inputs used to measure their fair values. Fair value is defined as the exchange price that would be received for an asset or an exit price that would be paid to transfer a liability in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. The Company measures fair value based on a three-tier hierarchy, which prioritizes the inputs used in the valuation methodologies in measuring fair value as follows:

Level 1—Observable inputs such as unadjusted, quoted prices in active markets for identical assets or liabilities at the measurement date.

Level 2—Inputs (other than quoted prices included in Level 1) are either directly or indirectly observable for the assets or liabilities. These include quoted prices for similar assets or liabilities in active markets and quoted prices for identical or similar assets or liabilities in markets that are not active.

Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

In determining fair value, the Company utilizes quoted market prices, or valuation techniques that maximize the use of observable inputs and minimize the use of unobservable inputs to the extent possible as well as considers counterparty credit risk in its assessment of fair value.

There were no transfers into or out of Level 3 for any of the periods presented.

The Company’s fair value measurements as of September 30, 2022 and December 31, 2021 were as follows (in thousands):


	September 30, 2022
	Level 1		Level 2		Level 3		Balance
Assets:
Cash equivalents:
Money market funds	$	22,751	$	—	$	—	$	22,751
Marketable securities:
U.S. government debt securities		35,304		—		—		35,304
Commercial paper		—		30,318		—		30,318
Corporate bonds		—		28,014		—		28,014
Total marketable securities		35,304		58,332		—		93,636
Total assets	$	58,055	$	58,332	$	—	$	116,387

	December 31, 2021
	Level 1		Level 2		Level 3		Balance
Assets:
Cash equivalents:
Money market funds	$	30,557	$	—	$	—	$	30,557
Marketable securities:
U.S. government debt securities		3,979		—		—		3,979
Commercial paper		—		54,363		—		54,363
Corporate bonds		—		56,135		—		56,135
Total marketable securities		3,979		110,498		—		114,477
Total assets	$	34,536	$	110,498	$	—	$	145,034

Summary of Significant Accounting Policies

Leases

The Company adopted ASU No. 2016-02, Leases (Topic 842) on January 1, 2022, as discussed below in the section titled “Recently Adopted Accounting Standards”. Under Accounting Standards Codification (ASC) Topic 842, Leases, the Company determines if an arrangement is a lease at inception.

The Company leases office space in the U.S. and the U.K. under non-cancelable operating leases. Operating lease right-of-use (ROU) assets represent the Company’s right to use an underlying asset for the lease term and lease liabilities represent the Company’s obligation to make lease payments arising from the lease. Operating lease ROU assets and liabilities are recognized based on the present value of lease payments over the lease term at the commencement date of the lease. ROU assets also include any initial direct costs incurred and any lease payments made at or before the lease commencement date, less any lease incentive received. The Company uses the rate implicit in the lease in determining the present value of lease payments and, if that rate is not readily determinable, the Company uses its incremental borrowing rate commensurate with the lease term based on the information available at the date of lease commencement. The incremental borrowing rate reflects the rate of interest that a lessee would have to pay to borrow, on a collateralized basis over a similar term, an amount equal to the lease payments in a similar economic environment. The Company’s lease terms may include options to extend or terminate the lease when it is reasonably certain that the Company will exercise that option. Short-term leases with an initial term of 12 months or less are not recorded on the balance sheet. The Company does not have material short-term lease costs. Lease expense for lease payments is recognized on a straight-line basis over the lease term. For real estate leases, the Company does not separate lease and non-lease components. The Company’s lease agreements do not contain any material residual value guarantees or material restrictive covenants.

The Company’s non-lease components are primarily related to property taxes, insurance, and common area maintenance, which vary based on future outcomes, and are recognized as rent expense when incurred.

There have been no other significant changes in the Company’s accounting policies during the nine months ended September 30, 2022.

Recently Adopted Accounting Pronouncements

On January 1, 2022, the Company adopted ASU No. 2016-02, Leases (Topic 842) using the modified retrospective transition method (which permitted the Company to not restate the comparative period presented) and elected the package of practical expedients to not reassess whether any expired or existing contracts are or contain leases, carry forward its historical lease classification and not reassess initial direct costs for existing leases. The Company elected to not separate non-lease components from the associated lease components and to not recognize ROU assets and lease liabilities for leases with a term of twelve months or less. Upon adoption of ASC 842, the Company recorded operating ROU assets of $0.9 million, operating lease liabilities of $0.9 million, and derecognized deferred rent and other lease liabilities of $12,000. There was no material impact to the Company’s statements of operations and comprehensive loss upon adoption. Results and disclosures for the three and nine months ended September 30, 2022 are presented under ASC 842. Prior period amounts before January 1, 2022 have not been adjusted and continue to be reported in accordance with the Company’s historical accounting under previous lease guidance, ASC 840: Leases (Topic 840).

Recently Issued Accounting Pronouncements Not Yet Adopted

In June 2016, the FASB issued ASU No. 2016-13, Financial Instruments—Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments. The standard changes how entities will measure credit losses for most financial assets, including accounts and notes receivables. The standard will replace today’s “incurred loss” approach with an “expected loss” model, under which companies will recognize allowances based on expected rather than incurred losses. Entities will apply the standard’s provisions as a cumulative-effect adjustment to retained earnings as of the beginning of the first reporting period in which the guidance is effective. The effective date of this update for non-public companies is for fiscal years beginning after December 15, 2022 and interim periods therein. The Company estimates that adoption will not have a material impact on its consolidated financial statements.

In December 2019, the FASB issued ASU No. 2019-12, Income Taxes (Topic 740): Simplifying the Accounting for Income Taxes. The standard simplifies the accounting for income taxes by removing certain exceptions to the general principles in Topic 740 and also improves consistent application by clarifying and amending existing guidance. The effective date of this update for non-public companies is for fiscal years beginning after December 15, 2021 and interim periods within fiscal years beginning after December 15, 2022. The Company estimates that adoption will not have a material impact on its consolidated financial statements.

In August 2020, the FASB issued ASU 2020-06, Debt—Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging — Contracts in Entity’s Own Equity (Subtopic 815-40)—Accounting For Convertible Instruments and Contracts in an Entity’s Own Equity. The standard simplifies accounting for convertible instruments by removing major separation models required under current GAAP. Consequently, more convertible debt instruments will be reported as a single liability instrument with no separate accounting for embedded conversion features. ASU 2020-06 removes certain settlement conditions that are required for equity contracts to qualify for the derivative scope exception, which will permit more equity contracts to qualify for it. The standard also simplifies the diluted net income per share calculation in certain areas. The effective date of this update for non-public companies is for fiscal years beginning after December 15, 2023, including interim periods therein. Early adoption is permitted for fiscal years beginning after December 15, 2020 and interim periods therein. The Company is currently evaluating the impact that this new guidance will have on its consolidated financial statements.

There were no other significant updates to the recently issued accounting standards other than as disclosed herewith for the nine months ended September 30, 2022. Although there are several other new accounting pronouncements issued or proposed by the FASB, the Company does not believe any of those accounting pronouncements have had or will have a material impact on its financial position or operating results.

Reclassifications

The Company reclassified certain prior period balances on its condensed consolidated balance sheet, statements of operations and comprehensive loss, and statement of cash flows to conform to the current period presentation. These balances related to amounts incurred from related party transactions with Carnot Pharma, LLC. The services related to these transactions have been completed and the Company's services agreement with Carnot Pharma, LLC has been terminated. These reclassifications had no effect on total liabilities, loss from operations, or net cash used in operating activities.

Description of Organization and Summary of Significant Accounting Policies (Tables)

9 Months Ended

Sep. 30, 2022

Accounting Policies [Abstract]

Schedule of Fair Value Measurements

The Company’s fair value measurements as of September 30, 2022 and December 31, 2021 were as follows (in thousands):


	September 30, 2022
	Level 1		Level 2		Level 3		Balance
Assets:
Cash equivalents:
Money market funds	$	22,751	$	—	$	—	$	22,751
Marketable securities:
U.S. government debt securities		35,304		—		—		35,304
Commercial paper		—		30,318		—		30,318
Corporate bonds		—		28,014		—		28,014
Total marketable securities		35,304		58,332		—		93,636
Total assets	$	58,055	$	58,332	$	—	$	116,387

	December 31, 2021
	Level 1		Level 2		Level 3		Balance
Assets:
Cash equivalents:
Money market funds	$	30,557	$	—	$	—	$	30,557
Marketable securities:
U.S. government debt securities		3,979		—		—		3,979
Commercial paper		—		54,363		—		54,363
Corporate bonds		—		56,135		—		56,135
Total marketable securities		3,979		110,498		—		114,477
Total assets	$	34,536	$	110,498	$	—	$	145,034

Stock-Based Compensation - Summary of Stock Option Activities (Details) - USD ($)
$ / shares in Units, $ in Thousands

9 Months Ended

12 Months Ended

Sep. 30, 2022

Dec. 31, 2021

Share-Based Payment Arrangement [Abstract]

Number of options outstanding, beginning of period

2,922,135

Number of options granted

1,673,932

Number of options, cancelled and forfeited

(62,646)

Number of options exercised

Number of options outstanding, ending of period

4,533,421

2,922,135

Number of options, vested and expected to vest

^[1]

4,488,421

Number of options exercisable, end of period

1,499,959

Weighted average exercise price outstanding, beginning of period

$ 3.62

Weighted average exercise price, options granted

7.80

Weighted average exercise price, options cancelled and forfeited

4.18

Weighted average exercise price, options exercised

Weighted average exercise price outstanding, end of period

5.16

$ 3.62

Weighted average exercise price, options vested and expected to vest

^[1]

5.13

Weighted average exercise price, options exercisable

$ 3.25

Weighted average remaining contracted terms (in years) outstanding, beginning of period

9 years 1 month 20 days

Weighted average remaining contracted terms (in years) outstanding, end of period

8 years 8 months 15 days

Weighted average remaining contracted terms (in years), vested and expected to vest

^[1]

8 years 8 months 15 days

Weighted average remaining contracted terms (in years), exercisable at end of period

8 years 3 months 7 days

Aggregate intrinsic value outstanding, beginning of period

$ 21,144

Aggregate intrinsic value options exercised

Aggregate intrinsic value outstanding, end of period

4,285

$ 21,144

Aggregate intrinsic value options vested and expected to vest

^[1]

4,285

Aggregate intrinsic value options exercisable

$ 2,338

[1]	(1) Excludes 45,000 stock options awards outstanding for the period ended September 30, 2022, subject to only performance conditions that have been assessed and deemed not probable.

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Cash flows from operating activities:
Net loss	$ (37,482)	$ (36,935)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation	5,096	2,583
Non-cash operating lease expense	329	0
Change in fair value of redeemable convertible preferred stock tranche liability	0	11,718
Amortization of premiums and accretion of discounts on investments	223	83
Foreign currency loss (gain) from remeasurement	2,220	(245)
Changes in operating assets and liabilities:
Prepaid expenses and other assets	1,219	(11,103)
Long-term assets	(72)	(2,633)
Accounts payable	91	1,287
Accrued liabilities	(188)	1,791
Operating lease liabilities	(356)	0
Net cash used in operating activities	(28,920)	(28,188)
Cash flows from investing activities:
Purchase of marketable securities	(81,249)	(106,919)
Proceeds from maturities of marketable securities	101,411	0
Net cash provided by investing activities	20,162	(106,919)
Cash flows from financing activities
Proceeds from issuance of common stock sold in initial public offering, net issuance costs		83,144
Proceeds from issuance of redeemable convertible preferred stock, net of issuance costs	0	93,939
Proceeds from the exercise of stock options	0	111
Net cash provided by financing activities	0	177,194
Effect of exchange rate changes on cash and cash equivalents	(2,220)	245
Net change in cash and cash equivalents	(10,978)	42,332
Cash and cash equivalents at beginning of period	46,922	20,487
Cash and cash equivalents at end of period	35,944	62,819
Supplemental disclosure of cash operating activities:
Conversion of redeemable convertible preferred stock to common stock		152,759
Cash paid for leases included in operating cash outflows	345	0
Supplemental disclosure of non-cash investing and financing activities:
Right-of-use assets obtained in exchange for lease liabilities	$ 915	$ 0

Condensed Consolidated Statements of Redeemable Convertible Preferred Stock and Stockholder's Deficit (Unaudited) - USD ($) $ in Thousands	Total	Redeemable Convertible Preferred Stock	Common Stock [Member]	Additional Paid-in Capital [Member]	Accumulated Deficit [Member]	Accumulated Other Comprehensive Loss [Member]
Beginning balance at Dec. 31, 2020		$ 46,551
Beginning balance (in shares) at Dec. 31, 2020		7,140,157
Beginning balance at Dec. 31, 2020	$ (24,983)		$ 1	$ 3,152	$ (28,136)	$ 0
Beginning balance, shares at Dec. 31, 2020			3,418,751
Series A-1 Preferred Stock Issuance (net of issuance costs and tranche liability)		$ 33,978
Series A-1 Preferred Stock Issuance (net of issuance costs and tranche liability), shares		4,358,972
Reclassification of redeemable convertible preferred stock tranche liability upon settlement		$ 12,269
Exercise of stock options and release of restricted stock awards	105			105
Exercise of stock options and release of restricted stock awards, shares			64,047
Stock-based compensation	297			297
Net loss	(18,601)				(18,601)	0
Ending balance at Mar. 31, 2021	(43,182)		$ 1	3,554	(46,737)
Ending balance, shares at Mar. 31, 2021			3,482,798
Ending balance at Mar. 31, 2021		$ 92,798
Ending balance (in shares) at Mar. 31, 2021		11,499,129
Beginning balance at Dec. 31, 2020		$ 46,551
Beginning balance (in shares) at Dec. 31, 2020		7,140,157
Beginning balance at Dec. 31, 2020	(24,983)		$ 1	3,152	(28,136)	0
Beginning balance, shares at Dec. 31, 2020			3,418,751
Reclassification of redeemable convertible preferred stock tranche liability upon settlement	(12,269)
Net loss	(36,935)
Ending balance at Sep. 30, 2021	176,661		$ 3	241,747	(65,071)	(18)
Ending balance, shares at Sep. 30, 2021			26,199,262
Beginning balance at Mar. 31, 2021		$ 92,798
Beginning balance (in shares) at Mar. 31, 2021		11,499,129
Beginning balance at Mar. 31, 2021	(43,182)		$ 1	3,554	(46,737)
Beginning balance, shares at Mar. 31, 2021			3,482,798
Series A-1 Preferred Stock Issuance (net of issuance costs and tranche liability)		$ 59,961
Series A-1 Preferred Stock Issuance (net of issuance costs and tranche liability), shares		3,846,150
Exercise of stock options and release of restricted stock awards	6			6
Exercise of stock options and release of restricted stock awards, shares			7,158
Stock-based compensation	1,050			1,050
Net loss	(8,719)				(8,719)
Ending balance at Jun. 30, 2021	(50,845)		$ 1	4,610	(55,456)	0
Ending balance, shares at Jun. 30, 2021			3,489,956
Ending balance at Jun. 30, 2021		$ 152,759
Ending balance (in shares) at Jun. 30, 2021		15,345,279
Vesting Of Restricted Stock Awards Shares			4,027
Proceeds from issuance of common stock in initial public offering	83,144		$ 1	83,143
Proceeds from issuance of common stock in initial public offering, Shares			7,360,000
Conversion of redeemable convertible preferred stock to common stock upon initial public offering	152,759	$ (152,759)	$ 1	152,758
Conversion of redeemable convertible preferred stock to common stock upon initial public offering, Shares		(15,345,279)	15,345,279
Stock-based compensation	1,236			1,236
Other comprehensive loss	(18)					(18)
Net loss	(9,615)				(9,615)
Ending balance at Sep. 30, 2021	176,661		$ 3	241,747	(65,071)	(18)
Ending balance, shares at Sep. 30, 2021			26,199,262
Beginning balance (in shares) at Dec. 31, 2021		0
Beginning balance at Dec. 31, 2021	167,203		$ 3	242,939	(75,616)	(123)
Beginning balance, shares at Dec. 31, 2021			26,235,317
Vesting Of Restricted Stock Awards Shares			9,451
Stock-based compensation	1,541			1,541
Other comprehensive loss	(398)					(398)
Net loss	(13,204)				(13,204)
Ending balance at Mar. 31, 2022	155,142		$ 3	244,480	(88,820)	(521)
Ending balance, shares at Mar. 31, 2022			26,244,768
Beginning balance (in shares) at Dec. 31, 2021		0
Beginning balance at Dec. 31, 2021	167,203		$ 3	242,939	(75,616)	(123)
Beginning balance, shares at Dec. 31, 2021			26,235,317
Net loss	(37,482)
Ending balance at Sep. 30, 2022	134,359		$ 3	248,035	(113,098)	(581)
Ending balance, shares at Sep. 30, 2022			26,348,371
Ending balance (in shares) at Sep. 30, 2022		0
Beginning balance at Mar. 31, 2022	155,142		$ 3	244,480	(88,820)	(521)
Beginning balance, shares at Mar. 31, 2022			26,244,768
Vesting Of Restricted Stock Awards Shares			82,633
Stock-based compensation	1,772			1,772
Other comprehensive loss	(83)					(83)
Net loss	(14,596)				(14,596)
Ending balance at Jun. 30, 2022	142,235		$ 3	246,252	(103,416)	(604)
Ending balance, shares at Jun. 30, 2022			26,327,401
Vesting Of Restricted Stock Awards Shares			20,970
Stock-based compensation	1,783			1,783
Other comprehensive loss	23					23
Net loss	(9,682)				(9,682)
Ending balance at Sep. 30, 2022	$ 134,359		$ 3	$ 248,035	$ (113,098)	$ (581)
Ending balance, shares at Sep. 30, 2022			26,348,371
Ending balance (in shares) at Sep. 30, 2022		0

Description of Organization and Summary of Significant Accounting Policies (Policies)

9 Months Ended

Sep. 30, 2022

Accounting Policies [Abstract]

Organization

Basis of Presentation and Principles of Consolidation

Initial Public Offering

Liquidity

Use of Estimates

The three months ended as of September 30, 2022 included a reversal of $1.5 million of clinical expenses due to actual results differing from prior quarter estimates.

Concentration of Credit Risk

Risks and Uncertainties

Segments

Fair Value Measurement

Level 1—Observable inputs such as unadjusted, quoted prices in active markets for identical assets or liabilities at the measurement date.

Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

There were no transfers into or out of Level 3 for any of the periods presented.

The Company’s fair value measurements as of September 30, 2022 and December 31, 2021 were as follows (in thousands):


	September 30, 2022
	Level 1		Level 2		Level 3		Balance
Assets:
Cash equivalents:
Money market funds	$	22,751	$	—	$	—	$	22,751
Marketable securities:
U.S. government debt securities		35,304		—		—		35,304
Commercial paper		—		30,318		—		30,318
Corporate bonds		—		28,014		—		28,014
Total marketable securities		35,304		58,332		—		93,636
Total assets	$	58,055	$	58,332	$	—	$	116,387

	December 31, 2021
	Level 1		Level 2		Level 3		Balance
Assets:
Cash equivalents:
Money market funds	$	30,557	$	—	$	—	$	30,557
Marketable securities:
U.S. government debt securities		3,979		—		—		3,979
Commercial paper		—		54,363		—		54,363
Corporate bonds		—		56,135		—		56,135
Total marketable securities		3,979		110,498		—		114,477
Total assets	$	34,536	$	110,498	$	—	$	145,034

Leases

There have been no other significant changes in the Company’s accounting policies during the nine months ended September 30, 2022.

Recent Accounting Procurement

Recently Adopted Accounting Pronouncements

Recently Issued Accounting Pronouncements Not Yet Adopted

Reclassifications

Stock-Based Compensation - Summary of Stock Option Activities (Parenthetical) (Details)	9 Months Ended
	Sep. 30, 2022 shares
Performance Shares [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock Option Award Outstanding	45,000

Redeemable Convertible Preferred Stock - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended		9 Months Ended
	May 31, 2021	Mar. 31, 2021	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2021	Aug. 12, 2021	Jun. 30, 2021	Dec. 31, 2020
Temporary Equity [Line Items]
Proceeds from issuance of redeemable convertible preferred stock and related tranche rights, net of issuance costs			$ 0	$ 93,939
Redeemable convertible preferred stock tranche liability				$ 0				$ 551
Common stock			26,567,681		26,567,681
Series A1 Redeemable Convertible Preferred Stock [Member]
Temporary Equity [Line Items]
Stock issued during period shares new issues		4,358,972
Proceeds from issuance of redeemable convertible preferred stock and related tranche rights, net of issuance costs		$ 34,000
Redeemable convertible preferred stock tranche liability		$ 12,300
Series B Redeemable Convertible Preferred Stock [Member]
Temporary Equity [Line Items]
Stock issued during period shares new issues	3,846,150
Proceeds from issuance of redeemable convertible preferred stock and related tranche rights, net of issuance costs	$ 60,000
Redeemable Convertible Preferred Stock [Member]
Temporary Equity [Line Items]
Temporary Equity, Shares Outstanding		11,499,129	0		0	15,345,279	15,345,279	7,140,157
Preferred dividend, per share			$ 0	$ 0

Condensed Consolidated Statements of Redeemable Convertible Preferred Stock and Stockholder's Deficit (Unaudited) (Parenthetical) - USD ($) $ in Thousands	3 Months Ended
	Sep. 30, 2021	Jun. 30, 2021	Mar. 31, 2021
Series A1 Preferred Stock [Member]
Stock issuance cost			$ 22
Series B Preferred Stock [Member]
Stock issuance cost		$ 39
Common Stock [Member]
Stock issuance cost	$ 8,856

Certain Balance Sheet Accounts - Summary of Other Long-Term Assets (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Balance Sheet Related Disclosures [Abstract]
Total other long-term assets	$ 141	$ 70

Certain Balance Sheet Accounts - Summary of Prepaid Expenses and Other Current Assets (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Balance Sheet Related Disclosures [Abstract]
Recoverable research and development tax credits	$ 5,066	$ 6,523
Prepaid research and development expenses	3,033	2,906
Prepaid expenses	1,898	1,491
Other assets	555	852
Total prepaid expenses and other current assets	$ 10,552	$ 11,772

Condensed Consolidated Balance Sheets (Parenthetical) - $ / shares	Sep. 30, 2022	Dec. 31, 2021
Statement of Financial Position [Abstract]
Common stock, par value	$ 0.0001	$ 0.0001
Common stock, shares authorized	250,000,000	250,000,000
Common stock, shares issued	26,567,681	26,567,681
Common stock, shares outstanding	26,567,681	26,567,681

Investments - Investments consists of available-for-sale securities (Details) - USD ($) $ in Thousands	9 Months Ended	12 Months Ended
	Sep. 30, 2022	Dec. 31, 2021
Short Term Marketable Securities [Member]
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	$ 87,216	$ 89,594
Unrealized Loss	(541)	(36)
Estimated Fair Value	86,675	89,558
Long Term Marketable Securities [Member]
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	7,001	25,006
Unrealized Loss	(40)	(87)
Estimated Fair Value	6,961	24,919
US Government Debt Securities [Member] \| Short Term Marketable Securities [Member]
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	35,531
Unrealized Loss	(227)
Estimated Fair Value	35,304
US Government Debt Securities [Member] \| Long Term Marketable Securities [Member]
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	0	3,996
Unrealized Loss	0	(17)
Estimated Fair Value	0	3,979
Corporate Bonds [Member] \| Short Term Marketable Securities [Member]
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	21,367	35,231
Unrealized Loss	(314)	(35)
Estimated Fair Value	21,053	35,196
Corporate Bonds [Member] \| Long Term Marketable Securities [Member]
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	7,001	21,010
Unrealized Loss	(40)	(70)
Estimated Fair Value	6,961	20,940
Commercial Paper [Member] \| Short Term Marketable Securities [Member]
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	30,318	54,363
Unrealized Loss	0	(1)
Estimated Fair Value	$ 30,318	$ 54,362

Stock-Based Compensation - Summary of Assumptions Used in Black-Scholes Model (Details)	9 Months Ended
	Sep. 30, 2022
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Risk-free interest rate, Minimum	1.69%
Risk-free interest rate, Maximum	3.03%
Dividend yield	0.00%
Minimum [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expected term (in years)	5 years 6 months
Expected volatility, Minimum	77.33%
Maximum [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expected term (in years)	6 years 6 months
Expected volatility, Maximum	80.54%

Description of Organization and Summary of Significant Accounting Policies - Schedule of Fair Value Measurements (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Assets:
Assets, Fair Value Disclosure	$ 116,387	$ 145,034
Money Market Funds [Member]
Assets:
Assets, Fair Value Disclosure	22,751	30,557
US Government Debt Securities [Member]
Assets:
Assets, Fair Value Disclosure	35,304	3,979
Corporate Bonds [Member]
Assets:
Assets, Fair Value Disclosure	28,014	56,135
Commercial Paper [Member]
Assets:
Assets, Fair Value Disclosure	30,318	54,363
Total Marketable Securities [Member]
Assets:
Assets, Fair Value Disclosure	93,636	114,477
Level 1 [Member]
Assets:
Assets, Fair Value Disclosure	58,055	34,536
Level 1 [Member] \| Money Market Funds [Member]
Assets:
Assets, Fair Value Disclosure	22,751	30,557
Level 1 [Member] \| US Government Debt Securities [Member]
Assets:
Assets, Fair Value Disclosure	35,304	3,979
Level 1 [Member] \| Corporate Bonds [Member]
Assets:
Assets, Fair Value Disclosure	0	0
Level 1 [Member] \| Commercial Paper [Member]
Assets:
Assets, Fair Value Disclosure	0	0
Level 1 [Member] \| Total Marketable Securities [Member]
Assets:
Assets, Fair Value Disclosure	35,304	3,979
Level 2 [Member]
Assets:
Assets, Fair Value Disclosure	58,332	110,498
Level 2 [Member] \| Money Market Funds [Member]
Assets:
Assets, Fair Value Disclosure	0	0
Level 2 [Member] \| US Government Debt Securities [Member]
Assets:
Assets, Fair Value Disclosure	0	0
Level 2 [Member] \| Corporate Bonds [Member]
Assets:
Assets, Fair Value Disclosure	28,014	56,135
Level 2 [Member] \| Commercial Paper [Member]
Assets:
Assets, Fair Value Disclosure	30,318	54,363
Level 2 [Member] \| Total Marketable Securities [Member]
Assets:
Assets, Fair Value Disclosure	58,332	110,498
Level 3 [Member]
Assets:
Assets, Fair Value Disclosure	0	0
Level 3 [Member] \| Money Market Funds [Member]
Assets:
Assets, Fair Value Disclosure	0	0
Level 3 [Member] \| US Government Debt Securities [Member]
Assets:
Assets, Fair Value Disclosure	0	0
Level 3 [Member] \| Corporate Bonds [Member]
Assets:
Assets, Fair Value Disclosure	0	0
Level 3 [Member] \| Commercial Paper [Member]
Assets:
Assets, Fair Value Disclosure	0	0
Level 3 [Member] \| Total Marketable Securities [Member]
Assets:
Assets, Fair Value Disclosure	$ 0	$ 0

Commitments and Contingencies - Additional Information (Details) $ in Millions	1 Months Ended	3 Months Ended		9 Months Ended
	Nov. 30, 2021 SquareFeet	Sep. 30, 2022 USD ($)	Sep. 30, 2021 USD ($)	Sep. 30, 2022 USD ($)	Sep. 30, 2021 USD ($)	May 31, 2021
Commitments and Contingencies Disclosure [Abstract]
Rent expense \| $		$ 0.1	$ 0.1	$ 0.4	$ 0.1
Operating lease, term of contract	39 months					24 months
Operating lease, total space of the office \| SquareFeet	5,000
Additional Lessee Operating Lease Term Of Contract	3 years
Operating weighted average lease term		1 year 9 months 18 days		1 year 9 months 18 days
Weighted-average incremental borrowing rate		7.50%		7.50%

Commitments and Contingencies - future minimum lease payments (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Jan. 01, 2022
Leases [Abstract]
2022 (remaining 3 months)	$ 112
2023	309
2024	172
2025	15
Total undiscounted lease payments	608
Present value adjustment	(37)
Total operating lease liabilities	$ 571	$ 900

Certain Balance Sheet Accounts - Summary of Accrued Expenses (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Balance Sheet Related Disclosures [Abstract]
Accrued research and development expenses	$ 1,897	$ 2,159
Accrued payroll expenses	2,149	2,220
Other accrued expenses	388	248
Total accrued expenses	$ 4,434	$ 4,627

Redeemable Convertible Preferred Stock Tranche Liability - Schedule of Valuation of The Redeemable Convertible Preferred Stock Tranche Liability (Details) - Series A 1 Tranche Call Option [Member]	9 Months Ended
	Sep. 30, 2022 $ / shares
Temporary Equity [Line Items]
Discount rate	0.10%
Dividend yield	0.00%
Strike price	$ 7.80
Minimum [Member]
Temporary Equity [Line Items]
Estimated fair value of redeemable convertible preferred stock	$ 6.94
Expected term (years)	3 months
Probability of milestone achievement	80.00%
Fair value of each tranche feature	$ 0.86
Maximum [Member]
Temporary Equity [Line Items]
Estimated fair value of redeemable convertible preferred stock	$ 11.10
Expected term (years)	5 months 12 days
Probability of milestone achievement	100.00%
Fair value of each tranche feature	$ 3.32